Abstracts CSC2008


Biological and Medicinal Chemistry Division

Sunday AM

BM1Salon 7

Altered Proteins

Organizer(s) - Ronald Kluger
Chair(s) - Stephen Withers

08:40 00021 Engineered Fluorescent Proteins and the Development of Genetically Encoded Biosensors Ai H.-w., *$Campbell R.E.
09:20 00022 Novel b-Peptides from L-Aspartic Acid and b-Amino-L-Alanine: Synthesis, Solution Conformation, Stability, and Cytotoxicity Studies Ahmed S., *$Kaur K., Sprules T., Beleid R.
09:40 Coffee Break
10:00 00023 Analysis of phnP from the Carbon-Phosphorus Lyase Pathway He S.-M., Podzelinska K., Yakunin A., Edwards A., Hove-Jensen B., Jia Z., *$Zechel D.L.
10:40 00024 Engineering of P450 Enzymes for Biocatalysis and Nanobiochemistry *$Auclair K.
11:20 End of Session


REMINDER
11:25 CIC Medal Lecture presented by John Vederas in Hall D

BM2Salon 11

Carbohydrate Chemistry and Glycobiology (Joint with OR) (joint with OR2)

Organizer(s) - Christopher Cairo and Chang-Chun Ling
Chair(s) - Chang-Chun Ling

08:00 00025 Synthesis of Potential Neuraminidase Inhibitors Mohan S., *Pinto B.M.
08:20 00026 Glycosylation at O-4 of N-Acetylglucosamine $Hendel J.L., Wang J.-W., *Auzanneau F.-I.
08:40 00027 Building Carbohydrates on the Dioxanone Scaffold: Stereocontrolled Approach to Rare Monosaccharides $Palyam N., *Majewski M.
09:00 00028 An STD-NMR Spectroscopy Investigation of Glycosidase Mutants Leads to the Discovery of a New Family of beta-Glucosidase Inhibitors *$Jakeman D.L., Sadeghi-Khomami A.
09:40 Coffee Break
10:00 00029 Glycosylsulfonylhydrazides in Protecting Group Free Glycosidation Reactions *$Nitz M., Gudmundsdottir A.V.
10:20 00030 PET Imaging Agents for in vitro Labeling of Recombinant Glucocerebrosidase, the Enzyme Used for Treatment of Gaucher Disease Phenix C.P., Rempel B.P., Adam M.J., *$Withers S.G.
10:40 00031 Mapping of the Protective Epitope of the b1,2-Mannan from Candida albicans and Prospects for a Synthetic Conjugate Vaccine *$Bundle D.R., Nycholat C.M., Lipinski T., Wu X., Yasui Y., Cheriaparambil S., Rennie R.P.
11:20 End of Session


REMINDER
11:25 CIC Medal Lecture presented by John Vederas in Hall D

BM3Salon 10

Chemical Biology: Molecular Probes and Organic Biomaterials (Joint with OR) (joint with OR5)

Organizer(s) - David Vocadlo and Fraser Hof
Chair(s) - Jeremy Wulff

08:00 00032 Synthesis and Characterization of a Long, Rigid Photo-Switchable Cross-Linker for Peptide Structural Change Zhang F., Sadovski O., *$Woolley G.A.
08:20 00033 The Chemical Biology of Amanitins Perrin D.M., May J.P., Dietrich D., Blanc A., Pellicelli J., Fournier P.
08:40 00034 Engineering Peptides and Proteins as Molecular Probes of Endogenous Protein Localization and Dynamics in Live Cells Ibraheem A., Cheng Z., *$Campbell R.E.
09:00 00035 Probing Neuroreceptors and Ion Channels Using Unnatural Amino Acids Dougherty D.A.
09:40 Coffee Break
10:00 00036 Mimicking the Function of Eggshell Matrix Proteins: Role of Multiplets of Charged Amino Acid Residues and Self-Assembly of Peptides in Biomineralization Parayil Kumaran A., *$Valiyaveettil S.
10:20 00037 Novel Biodegradable Polymers for Tissue Engineering *$Gillies E.R., Mequanint K., Wang Z., Atkins K.M., De Wit M.A., Knight D.K.
10:40 00038 Strategies to Improve Biocompatibility at Silicone Interfaces *$Brook M.A., Sheardown H.D., D'souza R., Chen Y., Zhao S., Shao Y., Awad N., Fawcett A.
11:00 00039 Peptide Self-Assembly: Collagen Triple Helices and Beta-Sheet Nanofibers *$Hartgerink J.D.
11:20 End of Session


REMINDER
11:25 CIC Medal Lecture presented by John Vederas in Hall D

BM5Salons 13/14

Computational Approaches to Drug Design (Joint with PT) (joint with PT4)

Organizer(s) - Jack Tuszynski
Chair(s) - Jack Tuszynski

08:00 00040 The Dance of Life and Death: Microtubule Polymerization Dynamics and the Mechanism of Action of Microtubule-Targeted Drugs *$Jordan M.A.
08:40 00041 Rational Design and Cytotoxicity of Novel Colchicine Derivatives Huzil J.T.
09:00 00042 Thermodynamics of Amyloid Fibril Formation: Molecular Theory of Solvation Perspective *Blinov N., Dorosh L., Wishart D., $Kovalenko A.
09:20 00043 Design of a Diverse Set of Commercially Available Screening Compounds: A First Step in Hit Identification *$Nilar S.H.
09:40 Coffee Break
10:00 00044 Conformational Relationships within the Tubulin Molecule: Implications for Rational Drug Design Luduena R., Joe P., Banerjee A.
10:40 00045 Predictions of Protein-Protein Interactions at the Atomic Scale Wodak S.J.
11:20 End of Session


REMINDER
11:25 CIC Medal Lecture presented by John Vederas in Hall D

BM6Salon 6

Protein NMR Spectroscopy (Joint with PT) (joint with PT8)

Organizer(s) - Leo Spyracopoulos
Chair(s) - Leo Spyracopoulos

08:00 00046 Folding and Interactions of E2 and E3 Enzymes in Ubiquitylation Safadi S.S., Serniwka S.A., Beasley S.A., Hristova V.A., Barber K.R., $Shaw G.S.
08:40 00047 Molecular Recognition and Regulation of the Eukaryotic Translation Intiation Factor eIF4E *$Borden K.L.B., Volpon L., Osborne M.
09:20 00048 Solution NMR Investigations into the Ff Bacteriophage Major Coat Protein Transmembrane Helix Dimer *$Goto N.K, Wu Y., Shih S.C.C.
09:40 Coffee Break
10:00 00049 Structural Studies of Protein Disulfide Isomerases Gehring K., Denisov A.Yu., Kozlov G.
10:40 00050 Flexible Modular Proteins in DNA Replication and Repair Machines Brosey C.A., Pretto D.I., Ehrhardt M.E., Chagot M.-E., *$Chazin W.J.
11:20 End of Session


REMINDER
11:25 CIC Medal Lecture presented by John Vederas in Hall D

BM7Salons 15/16

Single-Molecule Measurements in Biological Chemistry (Joint with AN and PT) (joint with AN7)

Organizer(s) - Nancy Forde and Hongbin Li
Chair(s) - Nancy Forde

08:00 Joint with AN7 and PT9 - See AN7

11:20 End of Session


REMINDER
11:25 CIC Medal Lecture presented by John Vederas in Hall D


Sunday PM

BM1Salon 7

Altered Proteins

Organizer(s) - Ronald Kluger
Chair(s) - David Zechel


REMINDER
13:20 Boehringer Ingelheim Award Lecture presented by Jamie Rich in Salon 11

14:00 00118 CE-LIF Characterization of Quantum Dots and their Conjugates with Proteins and Antibodies *Pereira M., $Lai E.P.C.
14:20 00119 Exploring the Potential of Lanthanide-Protein Conjugates for Multiplexed Assays *$Nitz M.
15:00 Coffee Break
15:20 00120 De novo Helical Peptides as Target Sequences for a Fluorogenic Protein Labelling Strategy *$Keillor J.W., Castonguay R., Guy J., Campos-Reales N.B., Caron K., Jacquier V.
16:00 00121 Methotrexate-Resistant Human Dihydrofolate Reductase: Directed Evolution of a Selectable Marker for Mammalian Cells *$Pelletier J.N., Volpato J.P., Mayotte N., Sauvageau G., Yachnin B., Berghuis A., Blanchet J.
16:20 End of Session


REMINDER
16:20 CCUCC Award Lecture presented by Vivian Yip in Salon 11

BM2Salon 11

Carbohydrate Chemistry and Glycobiology (Joint with OR) (joint with OR2)

Organizer(s) - Christopher Cairo and Chang-Chun Ling
Chair(s) - Todd Lowary

Boehringer Ingelheim Award Lecture presented by Jamie Rich

Introduction of Jamie Rich by David Bundle

13:20 00122 Thiosialosides: Synthesis and Immunochemistry *Rich J.R., $Bundle D.R.
14:00 00123 Synthesis and Testing of Mechanistic Probes of Polysialyltransferase Enzymes Morley T.J., *$Withers S.G., Wakarchuk W.W., Willis L.M.
14:20 00124 Mechanistic Studies on the MurNAc 6-Phosphate Lyase (MurQ) of Peptidoglycan Recycling Hadi T., Mayer C., *$Tanner M.E.
15:00 Coffee Break
15:20 00125 Isolation and Structural Characterization of Cyclic b-(1[2)-glucans from the Green Microalgae Chlorella Pyrenoidosa Reyes Suárez E., Budgen S.M., Kai F.B., Kralovec J.A., Noseda M.D., Barrow C.J., *$Grindley T.B.
15:40 00126 Glycosidase Inhibitors by Design and by Selection: Towards New Therapeutics and Proteomics Probes *Withers S.G., Tarling C.A., Zhang R., Brayer G.D., Buchini S., MacDonald J., Hekmat O., Reid S., Rempel B.P., Mahuran D., Tropak M., Buschiazzo A.
CCUCC Chemistry Doctoral Award Lecture presented by Vivian Yip

Introduction of Vivian Yip by Stephen Withers

16:20 00127 Family 4 Glycosidases Utilize a Redox-Elimination Mechanism in the Hydrolysis of a- and b-Glycosides Yip V.L.Y.
17:00 End of Session

BM3Salon 10

Chemical Biology: Molecular Probes and Organic Biomaterials (Joint with OR) (joint with OR5)

Organizer(s) - David Vocadlo and Fraser Hof
Chair(s) - Andreea Schmitzer and Christopher Cairo


REMINDER
13:20 Boehringer Ingelheim Award Lecture presented by Jamie Rich in Salon 11

14:00 00128 Probing Uncharted Physiology in Bacteria with (Old and New) Small Molecules Brown E.D.
14:20 00129 Probes for Interrogating the Influence of Cellular Metabolism on the Hepatitis C Virus *$Pezacki J.P.
14:40 00130 Ghrelin Analogues as New Probes for Cancer Imaging Rosita D., *$Luyt L.G.
15:00 Coffee Break
15:20 00131 Bioorganometallic Approach for the Electrochemical Detection of Kinase-Catalyzed Protein Phosphorylation Song H., Kerman K., *Kraatz H.B.
15:40 00132 Conventional Optical Drives for Detecting CD-Based ELISA Ou M.L., $Yu H.Z.
16:00 00133 Synthetic Receptors for Methylated Lysine: Pyrrole- and Indole-Derived Hosts Whiting A.L., Fowler N.M, Hof F.
16:20 End of Session


REMINDER
16:20 CCUCC Award Lecture presented by Vivian Yip in Salon 11

BM5Salons 13/14

Computational Approaches to Drug Design (Joint with PT) (joint with PT4)

Organizer(s) - Jack Tuszynski
Chair(s) - Jack Tuszynski


REMINDER
13:20 Boehringer Ingelheim Award Lecture presented by Jamie Rich in Salon 11

14:00 00134 Generation and Analysis of Biological Networks and their Potential Therapeutic Applications *$Parkinson J.
14:40 00135 Designing Paclitaxel Derivatives Based on Isotype Differences within an Intermediate Binding Site for Paclitaxel Located in the Microtubule's Nanopore Freedman H., $Tuszynski J.A.
15:00 Coffee Break
15:20 00136 Molecular Theory of Solvation for Complex Formation and Effective Interactions of Proteins and Synthetic Organic Nanoarchitectures in Solution *$Kovalenko A.
15:40 00137 A Spatial Model of Tumor-Host Interaction: Application of Chemotherapy *Hinow P.
16:20 End of Session


REMINDER
16:20 CCUCC Award Lecture presented by Vivian Yip in Salon 11

BM6Salon 6

Protein NMR Spectroscopy (Joint with PT) (joint with PT8)

Organizer(s) - Leo Spyracopoulos
Chair(s) - Leo Spyracopoulos


REMINDER
13:20 Boehringer Ingelheim Award Lecture presented by Jamie Rich in Salon 11

14:00 00138 NMR Spectroscopic Studies of Functional Enzyme Motions *$Loria J.P., Watt E.D, Doucet N., Wang Y., Berlow R.B., Mesecar A.D., Pegan S.
14:40 00139 Structural Studies of Intrinsically Disordered Proteins Using NMR Spectroscopy Yi S., Gall C., Brickenden A., Mokhtarzada S., *$Choy W.-Y.
15:00 Coffee Break
15:20 00140 Protein Structure and Dynamics in situ Julien O., Hoffman R., Baryshnikova O., Zhao X., Sykes B.D.
16:00 00141 NMR Solution Structure of PisI, a Group B Immunity Protein that Provides Protection Against the Type IIa Bacteriocin Piscicolin 126, PisA Martin-Visscher L.A., Sprules T., Gursky L.J., *$Vederas J.C.
16:20 End of Session


REMINDER
16:20 CCUCC Award Lecture presented by Vivian Yip in Salon 11

BM7Salons 15/16

Single-Molecule Measurements in Biological Chemistry (Joint with AN and PT) (joint with AN7)

Organizer(s) - Nancy Forde and Hongbin Li
Chair(s) - Hongbin Li

13:20 Joint with AN7 and PT9 - See AN7


REMINDER
13:20 Boehringer Ingelheim Award Lecture presented by Jamie Rich in Salon 11

17:00 End of Session


Monday AM

BM1Salon 7

Altered Proteins

Organizer(s) - Ronald Kluger
Chair(s) - Ronald Kluger

08:40 00420 Non-Sulfamate Suicide Inhibitors of Steroid Sulfatase *$Taylor S.D., Ahmed V., Liu Y., Qadoumi Z., Trinh J.
09:20 00421 Agility of Adding Artificial Amino Acids Ebhardt H.A., $Fahlman R.P.
09:40 Coffee Break
10:00 00422 Proteins Containing Fluorinated Methionines *$Honek J.F., Su Z.
10:40 00423 Directed Evolution of Redesigned Enzymes for Glycoside Synthesis *$Withers S.G., Kim Y.-W., Shim J.H., Hancock S., Rich J.R., Warren R.A.J., Aharoni A., Strydnaka N.C.J.
Bernard Belleau Award Lecture presented by Andrew Woolley in Salon 11

Introduction of Andrew Woolley by Ronald Kluger

11:20 00424 Photo-Switchable Proteins *Woolley G.A.
12:00 End of Session

BM2Salon 11

Carbohydrate Chemistry and Glycobiology (Joint with OR) (joint with OR2)

Organizer(s) - Christopher Cairo and Chang-Chun Ling
Chair(s) - Christopher Cairo

08:00 00425 Synthesis of 2-Deoxyglycosides via 2,3-Anhydrosugar Thioglycosides Hou D.J., *Lowary T.L.
08:20 00426 Kinetic Isotope Effects on Sialidase-Catalyzed Hydrolysis Reactions Chan J., Bennet A.J.
08:40 00427 Synthesis Of Potential a-Galactosidase Inhibitors Chakladar S., Wang Y., Cheng L., Bennet A.J.
09:00 00428 Probing the Conformational Itinerary of Glycosidases Using Conformationally-Restricted Substrate Analogues Bennet A.J., Wang Y., Cheng L., Chakladar S.
09:40 Coffee Break
10:00 00429 Investigating and Interfering with Cell Wall Recycling: A Strategy for Attenuating AmpC-Mediated Antibiotic Resistance Stubbs K.A., Balcewich M., Asgarali A., *$Vocadlo D.J., Scaffidi A., Stick R.V., Mark B.L.
10:20 00430 Synthesis and Evaluation of Phenolic Glycolipid Immunomodulators as Potential Vaccine Candidates for Mycobacterial Infections Elsaidi H., $Lowary T.L.
10:40 00431 The Role of Sialic Acid in the Formation of Protective Conformational Epitopes Jennings H.J.
11:20 End of Session


REMINDER
11:20 Bernard Belleau Award Lecture presented Andrew Woolley in Salon 11

BM6Salon 6

Protein NMR Spectroscopy (Joint with PT) (joint with PT8)

Organizer(s) - Leo Spyracopoulos
Chair(s) - Leo Spyracopoulos

08:00 00432 NMR Tools and Strategies for Structural Genomics and Structural Biology Arrowsmith C.
08:40 00433 Understanding cAMP-Dependent Allostery by NMR Spectroscopy *$Melacini G.
09:20 00434 A Novel NMR Assay for the Intrinsic and GAP-Accelerated GTPase Activity of Small G-Proteins: Characterization of Rheb and TSC2 *Marshall C.B., Plevin M.J., Li G.Y., Ho J., Stambolic V., $Ikura M.
09:40 Coffee Break
10:00 00435 Using NMR and Calorimetry to Study Protein Dynamics Mittermaier A.
10:40 00436 Solution and Solid-State NMR Studies of Natural and Transgenic Spider Silk Proteins *$Auger M., Leclerc J., Cloutier I., Gagné S.M., Pézolet M.
11:00 00437 Progress in Solid State NMR of Peripheral and Integral Membrane Proteins Ladizhansky V., Shi L., Zhong L., Bamm V., Brown L., Harauz G.
11:20 End of Session


REMINDER
11:20 Bernard Belleau Award Lecture presented by Andrew Woolley in Salon 11

BM7Salons 15/16

Single-Molecule Measurements in Biological Chemistry (Joint with AN and PT) (joint with AN7)

Organizer(s) - Nancy Forde and Hongbin Li
Chair(s) - Michel Grandbois

08:00 Joint with AN7 and PT9 - See AN7

11:20 End of Session


REMINDER
11:20 Bernard Belleau Award presented by Andrew Woolley in Salon 11


Monday PM

BM1Salon 7

Altered Proteins

Organizer(s) - Ronald Kluger
Chair(s) - John Honek

13:20 00537 Activation and Inhibition of the Cancer Chemotherapy Target Cytidine 5'-Triphosphate Synthase *$Bearne S.L., Lunn F.A.
14:00 00538 Further Travels around AroA's Active Site *$Berti P.J., Chindemi P.
14:40 00539 Biomimetic Acylation: Selectivity and Applications *$Kluger R., Tzvetkova S., Andrusiak T., Bunn S., Rathgeber S
15:00 Coffee Break
15:20 00540 The Mechanism of Prephenate Dehydrogenase Revealed Through Structural, Kinetic and Mutational Analyses Turnbull J.L., Christendat D.
15:40 00541 Investigating and Manipulating the Enzymes of Sialic Acid and Pseudaminic Acid Biosynthesis Liu F., *$Tanner M.E., Schoenhofen I.C., Logan S.M.
16:20 End of Session

BM3Salons 15/16

Chemical Biology: Molecular Probes and Organic Biomaterials (Joint with OR) (joint with OR5)

Organizer(s) - David Vocadlo and Fraser Hof
Chair(s) - Mark Nitz and David Zechel

13:20 00542 Alkaloid Biosynthesis in Periwinkle *$O'Connor S.E.
14:00 00543 Type III Polyketide Synthase Loci from Rhizobium leguminosarum and Synechococcus sp. Colpitts C., Lohans C., Askew C., Yost C., *Suh D.-Y.
14:20 00544 Synthesis and Activity of Olfaction and Gustation Inhibitors against Pest Insects *$Plettner E., Mudalige A.P., Gong Y., Castillo C., Nagabandi S.
14:40 00545 Probing Brassinin Oxidase and Brassinin Glucosyl Transferase, Fungal Detoxifying Enzymes from Plant Pathogens *$Pedras M.S.C., Minic Z., Sarma-Mamillapalle V.K., Jha M., Hossain M., Suchy M.
15:00 Coffee Break
15:20 00546 Lipase Resistant Phosphonolipids for Exogenous Lung Surfactant Therapy *$Schwan A.L., Davy J.A., Wang Z., Notter R.H, Wang Z.
15:40 00547 Molecular Beacon Detection of DNA and RNA Damage *$Loppnow G.R.
16:00 00548 Polyvalent Display of Cationic Motifs on Bacteriophage Qb with anti-Heparin Activity *Udit A.K., Everett C., Gale A.J., Kyle J.R., Ozkan M., $Finn M.G.
16:20 00549 Unprecedented in vitro Activity and in vivo Efficacy of Pre-Ordered Polymeric Heterobifunctional Ligands *$Bundle D.R., Kitov P.I., Paszkiewicz E., Lipinski T.
17:00 End of Session

BMPHall A

Posters

Organizer(s) - Robert Campbell and Todd Lowary
Chair(s) - Robert Campbell and Todd Lowary

From 17:00 until 19:00

17:00 00550 Modifying the Spectral Properties of a Red Fluorescent Protein Chica R.A., Allen B.D., $Mayo S.L.
17:00 00551 Potential Role of Tubedown in the Treatment of Ocular Diseases Islam T., Paradis H., Gendron R.L.
17:00 00552 Investigation of the Key Residues Involved in Binding of Anti-Cancer Ru(III)-Complexes via Functional Analysis of Site-Directed Mutants of Human Serum Transferrin Cetinbas N., *$Walsby C.J.
17:00 00553 Structural and Mutagenic Analysis of Inositol Dehydrogenase from Bacillus subtilis Zheng H., Van Straaten K.E., Sanders D.A.R., *$Palmer D.R.J.
17:00 00554 Structural and Kinetic Studies of Chimeric beta-Lactamases Clouthier C.M., Morin S., Gobeil S., Gagné S., $Pelletier J.N.
17:00 00555 NMR Evidence for Half-of-the-Sites Ni2+ Binding in Two Identical Active Sites of Escherichia coli Glyoxalase I *Su Z., Sukdeo N., Daub E., $Honek J.F.
17:00 00556 RNA Binding by the Spliceosomal Protein p14 Schellenberg M.J., $MacMillan A.M.
17:00 00557 The Effects of Protein Osmolytes and Detergent Chain Length on the Stability of the Integral Membrane Protein Glycerol Facilitator Baturin S.J., Galka J., *$O'Neil J.D.
17:00 00558 A Novel Strategy for the Synthesis of Sulfotyrosine-Bearing Peptides Ali A.M., *Taylor S.D.
17:00 00559 Phenylalanine Ammonia Lyase Activity in Organic Solvents *$D'Cunha G.B., Quinn A.J., Pickup M.J.
17:00 00560 A Convenient Route to N-[2-(Fmoc)-aminoethyl]glycine Esters and bis-N-Boc Protected Nucleobases *Wojciechowski F., $Hudson R.H.E.
17:00 00561 Suitably Protected Pseudoisocytosine and 2,6-Diamiopurine for Mild Acid Deprotection in PNA Oligomer Synthesis *Wojciechowski F., $Hudson R.H.E.
17:00 00562 Mechanistic Investigation of a Synthetically Modified DNAzyme: An RNaseA Mimic? Thomas J.M., *$Perrin D.M.
17:00 00563 Probing General Acid/Base Catalysis in the Hammerhead and Hairpin Ribozymes Thomas J.M., *$Perrin D.M.
17:00 00564 Characterization of the DNA Homolog of the RNA Dopamine Aptamer Walsh R., Blair D.A.D., Dedhar S., *$DeRosa M.C.
17:00 00565 Molecular Beacon Detection of DNA Damage due to Gamma Radiation Sparling S.B., $Loppnow G.R.
17:00 00566 Directed Evolution of Thermus aquaticus DNA Polymerase I for Improved Incorporation of Modified Nucleotides Hipolito C., $Perrin D.M.
17:00 00567 Cyclic DNA Nanostructures: From Synthetic Methodology to Utility for Three-Dimensional DNA Assemblies McLaughlin C.K., Aldaye F.A., $Sleiman H.F.
17:00 00568 RNA-Protein Interactions in a Gene Silencing Complex Gesner E.M., Makil N., *Duchaine T., $MacMillan A.M.
17:00 00569 Towards an Aptamer for Fumonisin B1 McKeague M., *DeRosa M.C.
17:00 00570 Dynamics for the RING Domain from Human TRAF6 by 15N NMR: Implications for Biological Function Markin C.J., $Spyracopoulos L.
17:00 00571 Dissecting the Enzymatic Mechanism of the Sialyltransferase CstII from Campylobacter jejuni by NMR Spectroscopy Chan P.H.W., Lee H.J., Wakarchuk W.W., Strynadka N.C.J., Withers S.G., $McIntosh L.P.
17:00 00572 Structural Characterization of Zn(II) Binding to HIV-1 Transactivator-of-Transcription Protein by Circular Dichroism and Nuclear Magnetic Resonance Spectroscopy Vo T.N., *O'Neil J.D.
17:00 00573 Structural Elucidation of Thuricin, a Two-Component Antimicrobial Peptide Sit C., *$Vederas J.C., Rea M.C., O'Connor P.M., Hill C., Ross R.P.
17:00 00574 Binding Study of Pi-Stacked Guanidinium Motif *Wang X., $Hof F.
17:00 00575 Synthesis of Enantiopure Pyrrolo(3,2-e)(1,4)diazepin-2-ones by Pictet-Spengler Cyclization Deaudelin P., *Lubell W.D.
17:00 00576 A Concise Total Synthesis of (±)-Acutifolone A *Liu H.J., Hsieh M.C.
17:00 00577 Efficient Synthesis of Hydroxyethylene Dipeptide Isostere of Phe-Aib Genest N., Lama T., Del Valle S., *Lubell W.D.
17:00 00578 An Iterative Approach to the Synthesis of Pseudo-Steroidal Beta-Sheet Mimetics Coopersmith K.A., Wulff J.E.
17:00 00579 Experimental and Theoretical Investigations of Acetohydroxamic Acid Tautomers *Sears D.N., Ying L., Sujino K.
17:00 00580 Design, Synthesis and Bioevaluation of 3,5-Bisarylmethylene-4-piperidone Derivatives as Antitumor Agents for Site Specific Delivery Potter E., *$Jha A., Youssef D., DeClercq E.
17:00 00581 Development of Butyrylcholinesterase Neuroimaging Ligands for the Early Diagnosis of Alzheimer's Disease Atkinson A., $Darvesh S., Joy E.E., Macdonald I.R., Martin E., *Pottie I.R.
17:00 00582 Antineoplastic 3,5-Bis(4-pyridylmethylene)-4-piperidone Derivatives: Novel Human Topoisomerase-IIa Inhibitors Jha M., Paul N.K., Jha A., DeClercq E.
17:00 00583 3,5-Bis(benzylidene)-4-piperidones: A Novel Class of Potent Antimycobacterial Agents which Stimulate Mitochondrial Respiration Das S., Das U., Bandy B., Stables J.P., *Dimmock J.R.
17:00 00584 Functionalised 3-Hydroxy-4-pyridinones for Alzheimer's Disease Therapy Scott L.E., Page B.D.G., Bowen M.L., Green D.E., Merkel M., Schugar H.J., $Orvig C.
17:00 00585 Substrate Analogues as Inhibitors and Mechanistic Probes of MenD from E. coli Fang M., Langman B., Ho K., *$Palmer D.R.J.
17:00 00586 Biochemical Investigations of Methionine c-Lyase 1 Moya I.A., *$Honek J.F.
17:00 00587 Peptide and Peptidomimetic Approaches for Developing Cancer Targeting Agents Ahmed S., *$Kaur K.
17:00 00588 Chemical Synthesis and Chemopreventive Evaluation of Natural Products Analogs, Application I: Chalcone Analogs *$Touaibia M.
17:00 00589 Synthesis and Evaluation of Small Molecule Inhibitors of Severe Acute Respiratory Syndrome 3C-Like Proteinase $Miyyapuram V., Zhang J., *Vederas J.C.
17:00 00590 Insulinomimetic Activity of Kaempferitrin from Leaves of Cinnamomum osmophloeum *$Tzeng Y.M., Chen K., Lee M.J.
17:00 00591 Ab initio Conformational Studies of Galactofuranose Richards M.R., $Lowary T.L.
17:00 00592 In vivo Synthesis of Complex Ganglioside Analogues by Metabolically Engineered Escherichia coli Strains Jacques S., Ling C.C., Samain E., *$Bundle D.R.
17:00 00593 Synthesis of Aza-C-glycosides as Potential Inhibitors of Glycosidases and Glycosyltransferases Sandbhor M., Williams D., Bhasin M., *$Zou W.
17:00 00594 Synthesis of ABO Blood Group Oligosaccharides for Glycosyl Transferase and Antigen Affinity Studies Meloncelli P., Lowary T.L.
17:00 00595 Studies Directed Towards the Synthesis of a CS-D Tetrasaccharide Ingram L.J., *Taylor S.D.
17:00 00596 Biological Evaluation of a-Galactosidase Inhibitors *Wang Y., Cheng L., Ko S., $Bennet A.J.
17:00 00597 Solution Structures of Tumor Antigen LeaLex and Two Trisaccharide Fragments Jackson T.A., Wang A., *Auzanneau F.-I.
17:00 00598 The Role of Sialic Acid Residues in T Cell Integrin Adhesion Sadek C.M., Strelkov I., *$Cairo C.W.
17:00 00599 Synthesis of Fluorinated Fructose Analogues for Use with PET $Cheeseman C.I., Grant T.N., Trayner B., West F.G.
17:00 00600 Investigating Multiple Free-Energy Relationships for the O-GlcNAcase-Catalyzed Hydrolysis of Glycosides *Macauley M.S., Greig I.R., $Vocadlo D.J.
17:00 00601 Identification of Biocatalysts for Glycosyl Transfer of C-3 Modified Galactopyranoses Rich J.R., Shim J.H., Chen H.-M., Wakarchuk W.W., Warren R.A.J., $Withers S.G.
17:00 00602 Investigating Unusual Forms of Glycosylation of Epidermal Growth Factor Repeats Whitworth G.E., Stubbs K.A., Vocadlo D.J.
17:00 00603 Synthesis of Sulfonium-Ion Analogs of Galactofuranose Rings Li J., *Lowary T.L.
17:00 00604 Studies of a Polyprenol Monophosphomannose-Dependent a-(1[6)-Mannosyltransferase Involved in Mycobacterial Lipoarabinomannan Biosynthesis Tam P.H., *$Lowary T.L.
17:00 00605 Synthesis of Lipoic Acid Tagged Glycolipids for Probing the Mycobacterial Cell Wall Assembly Peng W.J., *Lowary T.L.
17:00 00606 Synthesis of Glycoconjugate Related to Mycobacteria Cell Wall Liu C., *Richards M.R., $Lowary T.L.
17:00 00607 A Novel Method for in situ Generation of Glycosyl Iodides *$Lowary T.L., Martin A.D.
17:00 00608 Synthesis of Zwitterionic Oligosaccharides with the Potential to Stimulate T-Cell Responses Iynkkaran I., Ling C.C., *$Bundle D.R.
17:00 00609 Development of Fluorinated Carbohydrates as Mechanism-Based Inactivators of Glycosidases Rempel B.P., Withers S.G.
17:00 00610 Mechanistic Investigations of the Lipo-Oligosaccharide Sialyltransferase from Nisseria meningitidis Rakic B., Wakarchuk W.W., $Withers S.G.
17:00 00611 Deoxygenated Galactofuranosides and UDP-Galactofuranose Analogues as Probes for Mycobacterial Galalactofuranosyltransferases Zhou R., *$Lowary T.L.
17:00 00612 Synthesis of Polyacetylene Glycosides and Thioglycosides *Pan Y., $Lowary T.L., Tykwinski R.R.
17:00 00613 Altering Cell Surface Glycosylation State of T Cells Using the Staudinger Ligation Loka R.S, *$Cairo C.W
17:00 00614 An Efficient Chemoenzymatic Synthesis of a(2,8)-Oligosialic Acids Zuccolo A.J., $Ling C.C., *Zheng R.B.
17:00 00615 Elicitors: Stress-Driven Discovery of Secondary Metabolites from the Fungal Phytopathogen Leptosphaeria maculans Yu Y., *Pedras M.S.C.
17:00 00616 Synthesis of an Oxidatively Stable Analogue of the Antimicrobial Peptide, Lacticin 3147 A2 $Liu H., Pattabiraman V.R., *Vederas J.C.
17:00 00617 Syntheses and Antimicrobial Activity Testing of Lantibiotic-Siderophore Conjugates $Yoganathan S., Martin-Visscher L.A., Pattabiraman V.R., Cobb S.L., Sit C.S., *Vederas J.C.
17:00 00618 Analysis of Metabolic Responses of Brassica juncea to the Biotrophic Pathogen Albugo candida and Abiotic Stress Zheng Q.A., Jha A., *Pedras M.S.C., Rimmer S.R.
17:00 00623 Metabolic Profiling of Brassica napus Revealed Distinct Defense Responses against the Biotrophic Pathogen Plasmodiophora brassicae Zheng Q.A., Jha A., *Pedras M.S.C.
17:00 00619 Stereoselective Synthesis and Biological Activity of Gypsy Moth Pheromone Analogues *$Plettner E., Mudalige A.P., Nagabandi S.
17:00 00620 A Profluorophore Labeling Strategy for Cell Surface Glycoconjugates Key J.A., Romaniuk N.A., *$Cairo C.W.
17:00 00621 Aqueous Solvolysis of Heteroaryltrifluoroborates at Physiological Conditions by 19F-NMR Li Y., *Perrin D.M.
17:00 00622 Unexpected Reduction Reactions of Cytochrome P450cam Prasad B., Rojubally A., *$Plettner E.
17:00 00624 Design and Synthesis of Fluorescent Probes of Protein Tyrosine Phosphatase Activity Tulsi N.S., *$Cairo C.W.
17:00 00625 Mechanistic Study of the Antibiotic Resistance-Causing Enzyme Aminoglycoside N-6'-acetyltransferase Freiburger L.A., Mittermaier A., *$Auclair K.
17:00 00626 Binding Properties Comparison between Native and C-Terminus Truncated Pheromone Binding Proteins (PBPs) in Gypsy Moth Castillo C., Gong Y., *$Plettner E.
17:00 00627 Elucidating the Interaction between Inducer Peptide Pheromones and Membrane Receptors in Quorum Sensing van Belkum M.J., Derksen D.J., *$Vederas J.C.
17:00 00628 Library Screening Using a Novel "Beads on a Bead" Approach Coupled with a Fast Single-Bead MS/MS Deconvolution Enables High Throughput Discovery of Peptides for Molecular Imaging Amadei G.A., *$Luyt L.G., Cho C.F., Lewis J.D.
17:00 00629 The Association Pathway of an Insect Pheromone-Binding Protein with Ligands by Kinetic Studies Gong Y., *Plettner E.
17:00 00630 Biosynthesis of Ethyl Oleate in Honeybees, a Primer Pheromone that Regulates Behavioral Maturation Chen H., Castillo C., *Plettner E.
17:00 00631 Electrochemical Probing of HIV Proteins Using Ferrocene-Conjugated Peptides Kerman K., *Kraatz H.B.
17:00 00632 Amatoxins as Probes for Transcriptional Inhibition Dietrich D., May J.P., *$Perrin D.M.
17:00 00633 The Optimization of DNA Photodamage Detection on Microarray Slides Pinnock C.L., $Loppnow G.R.
17:00 00634 Interaction of the Fungal Phytotoxins Destruxin B and Sirodesmin PL with Crucifer Plants Khallaf I.S., *Pedras M.S.C.
17:00 00635 Probing the Metabolism of Crucifer Fungal Pathogens with Indole Glucosinolates Hossain S., *Pedras M.S.C.
17:00 00636 DRED: A Proof of Concept Perez-Pineiro R., Alvarez-Puebla R., Bravo-Vasquez J.P., Materi W., *Fenniri H.
17:00 00637 Evaluating Potential Inhibitors of Phytoalexin Detoxification by the Plant Pathogenic Fungus Leptosphaeria maculans Sarma-Mamillapalle V.K., Jha M., Pedras M.S.C.
17:00 00638 Fluorescent Labeled Rosette Nanotube St. Jules M., *$Fenniri H.
17:00 00639 Hock Cleavage of Cholesterol 5-Hydroperoxide: An Ozone-Free Pathway to the Cholesterol Ozonolysis Products Identified in Arterial Plaque and Brain Tissue Brinkhorst J., Nara S.J., *$Pratt D.A.

Tuesday AM

BM8Salon 2

Small Molecule Drug Design and Development (Joint with OR) (joint with OR11)

Organizer(s) - Amitabh Jha
Chair(s) - Donald Weaver

08:00 00846 Toward the Discovery and Development of Novel Therapies for the Treatment of Hepatitis C Virus Infection Beaulieu P.L.
08:40 00847 Synthesis and Biological Evaluation of Glycosylated Anti-Tumor Compounds Structurally Mimicking Anthracycline Antibiotics Shi W., *$Lowary T.L.
09:00 00848 Design of Inhibitors of the Enzyme Aminoglycoside 6'-N-Acetyltransferase Involved in Antibiotic Resistance *$Auclair K.
09:20 00849 Design, Synthesis, and Evaluation of Peptide-Based HCV Entry Inhibitors Algryani R., *$Kaur K., Douglas D., Kneteman N.
09:40 Coffee Break
10:00 00850 Comparing the Metabolomic Profiles of Different Streptomyces Bacteria Le C.H., Hayward R.J., *$Shipley P.R.
10:20 00851 Design of Vitamin D Receptor/Histone Deacetylase Inhibitor Hybrids as Potential Anticancer Compounds Gleason J.L., White J.H., Quach T.D., Tavera-Mendoza L.E., Dabbas B., Lamblin M., Hudon J., Liao X.
10:40 00852 Targeting an Ubiquitous Enzyme, ODCase: Discoveries and Lessons *$Kotra L.P., Pai E.F.
11:20 End of Session


REMINDER
11:25 Montreal Medal Lecture presented by Stan Brown in Hall D


Tuesday PM

BM4Salon 5

Chemistry and Biology of Nucleic Acids

Organizer(s) - Andrew MacMillan and Peter Unrau
Chair(s) - Andrew MacMillan and Peter Unrau

13:20 00997 Genetic Control by Metalloregulatory RNAs *$Winkler W., Dann C., Wakeman C., Ramesh A.
14:00 00998 Gene Regulation Mechanisms of Purine Riboswitches $Lafontaine D.A., Tremblay R., Mulhbacher J., Lemay J.F.
14:20 00999 Bridging the Gap: Molecular Dynamics and the Nucleotide Exchange Reaction in Elongation Factor Tu *$Wieden H.-J., Mercier E., Yawney D., Gray J.
14:40 01000 In Vitro Selection of a Sugar-Sensing DNAzyme *Lam C., Hollenstein M., Hipolito C., $Perrin D.M.
15:00 Coffee Break
15:20 01001 Chemically-Modified siRNA and AONs: Synthesis and Applications Watts J.K., Donga R., Lackey J., Bayó-Puxan N., Hassler M., Deleavey G., El-Sabahy M., Wazen N., Leroux J.C., Chan T.H., *$Damha M.J.
16:00 01002 Chelating versus Nonchelating N2-Modified Guanosines and their Fluorescent Response toward Metal Ions Martic S., *Wu G., $Wang S.
16:20 01003 Molecular Recognition Using Self Assembing Cyclodextrin-DNA Conjugates *$Linkletter B.A., Curran E.
16:40 01004 Structural Insights on Key Proteins at the Heart of the Spliceosome MacMillan A.M.
17:00 End of Session


Wednesday AM

BM4Riverview

Chemistry and Biology of Nucleic Acids

Organizer(s) - Andrew MacMillan and Peter Unrau
Chair(s) - Andrew MacMillan and Peter Unrau

08:00 01275 Discovery of a Novel Amidotransferase Involved in the Modification of Archaeal tRNA Masiyanise V., Phillips G., Maxwell A., El Yacoubi B., de Crecy-Lagard V., *$Iwata-Reuyl D.
08:40 01276 Uniform Accuracy in Ribosomal Protein Synthesis *$Kothe U., Rodnina M.V.
09:20 01277 A Study of Cation-Directed Self-Assembly of Guanosine Derivative Using NMR and ESI-MS Kwan I.C.M., Mo X., She Y.-M., $Wu G.
09:40 Coffee Break
10:00 01278 Nucleic Acid-Small Molecule Interactions: Structure and Binding Studies *$Johnson P.E., Tavares T.J., Neves M.
10:40 01279 Marked for Death: A Role of tRNAArg in Targeting Proteins for Degradation *$Fahlman R.P.
11:00 01280 In Vitro Screening for High Affinity siRNA Interactions with Hepatitis C Virus RNA Sagan S., Luebert C., *$Pezacki J.P.
11:20 01281 Folding of the S-Adenosylmethionine Riboswitch Heppell B., *$Lafontaine D.A.
11:40 01282 On the Discovery and Mechanism of Catalytic Nucleic Acids with a Protein-Like Repertoire Perrin D.M., Thomas J.M., Ting R.T., Hollenstein M., Hipolito C., Lam C.
12:00 End of Session

BM8Salon 3

Small Molecule Drug Design and Development (Joint with OR) (joint with OR11)

Organizer(s) - Amitabh Jha
Chair(s) - Virinder Parmar

08:20 01283 Greener Biocatalytic Route for the Synthesis of Nucleosides as Small Molecular Weight Drug Candidates *$Prasad A.K.
08:40 01284 Applications of Aziridines in PET Radiopharmaceutical Chemistry: Systematic Ring-Opening of Aziridines with Fluorinating Agents $van Oosten E.M., Stephenson K.A., Wilson A.A., Yudin A.K., Houle S., *Vasdev N.
09:00 01285 Biology Oriented Synthesis *$Waldmann H.
09:40 Coffee Break
10:00 01286 Design and Development of Disease Modifying Agents for Neurological Disorders *$Weaver D.F., Carter M.D., Barden C., Lu E., Jacobo S., Gao F., Beshara C., Tiedje K., Buhendwa M.G., Galloway T.
10:40 01287 Development of Phenothiazine Derivatives for the Treatment of Alzheimer's Disease *$Darvesh S., McDonald R.S., Darvesh K.V., Martin E.
11:00 01288 An Evaluation of Glucose Transport Inhibition as a Mechanism for Sensitizing Resistant Tumor Cells to Death Receptor Signalling Wood T.E., *Batey R.A., $Schimmer A.D., Dalili S.
11:20 01289 Molecular Modeling Study on a Chemically Diverse Series of Cyclogenase-2 Selective Inhibitors: Generation of Predictive Pharmacophore Model Using the Catalyst®/HypoGen® Module *$Chopra M.
11:40 End of Session


Wednesday PM

BM4Riverview

Chemistry and Biology of Nucleic Acids

Organizer(s) - Andrew MacMillan and Peter Unrau
Chair(s) - Andrew MacMillan and Peter Unrau

13:20 01403 Development of a New Class of Ribozyme and Study of the Folding Pathway of HDV Ribozyme *$Perreault J.P., Beaudoin J.D., Reymond C.
14:00 01404 A Novel and Highly Selective DNAzyme Sensor for Mercury Cations Hollenstein M., Hipolito C., $Perrin D.M.
14:20 01405 Aging-Related Oxidative DNA Damage: Charge Transfer through Telomeric Guanine Quadruplexes Cheng A.K.H., Huang Y.C., Sen D., *$Yu H.Z.
14:40 01406 A Pyrrolocytosine Analogue that Forms a Fourth Hydrogen Bond to Guanosine *Wojciechowski F., $Hudson R.H.E.
15:00 Coffee Break
15:20 01407 Applying Rolling Circle Amplification to DNAzyme Mediated Reactions for Biosensing *$Li Y., Ali M.M., Zhao W., Brook M.A., Pelton R.
16:00 01408 Design and Selection of Minimalist Protein-DNA Interactions *$Shin J.A.
16:20 01409 Progress and Prospects in Aptamer-Based Biosensors $DeRosa M.C.
16:40 01410 6S RNA Interactions with E. coli RNAP Characterized Using in vitro Selection Shephard L., Dobson N., *$Unrau P.J.
17:00 End of Session

BM8Salon 3

Small Molecule Drug Design and Development (Joint with OR) (joint with OR11)

Organizer(s) - Amitabh Jha
Chair(s) - Lakshmi Kotra

13:20 01411 Development of Natural Products Based Anti-Inflammatory and Antihypertensive Drugs *Parmar V.S.
14:00 01412 Synthesis and Evaluation of Osteotropic Fluoroquinolone Prodrugs for the Prevention and Treatment of Osteomyelitis *$Rafai Far A., Tanaka K.S.E., Houghton T.J., Kang T., Dietrich E., Lafontaine Y., Arhin F.F., Sarmiento I., Liu J., Srikumar R., Fadhil I., Laquerre K., Ostiguy V., Lehoux D., Moeck G., Parr T.R.
14:20 01413 Development of 3,5-bis(Benzylidene)-4-piperidone Analogs as Potent Antineoplastic Agents that Overcome Multidrug Resistance Mechanisms *Das U., Das S., Sakagami H., Molnar J., Kawase M., Balzarini J., De Clercq E., $Dimmock J.R., Stables J.P.
14:40 01414 Protecting the Intellectual Property for Medicinal Drugs and Other Inventions Mitchell M.
15:00 Coffee Break
15:20 01415 Carbocyclic Analogs of Penicillins: Effects of Substitution on Conformation and Hemiketal Stability Johnson J.W., Evanoff D.P., Goodfellow V.J., *Dmitrienko G.I.
15:40 01416 Cardiovascular Agents: Renin Inhibitors Kasani A., Stier M., Holsworth D.D., Maiti S.
16:00 01417 Design of Anti-inflammatory Cyclooxygenase and/or Lipoxygenase Inhibitors, Including Nitric Oxide Donor Prodrugs, Devoid of Adverse Ulcerogenic and Cardiovascular Effects *$Knaus E.
16:40 End of Session


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